amp-web-push-widget button.amp-subscribe { display: inline-flex; align-items: center; border-radius: 5px; border: 0; box-sizing: border-box; margin: 0; padding: 10px 15px; cursor: pointer; outline: none; font-size: 15px; font-weight: 500; background: #4A90E2; margin-top: 7px; color: white; box-shadow: 0 1px 1px 0 rgba(0, 0, 0, 0.5); -webkit-tap-highlight-color: rgba(0, 0, 0, 0); } /** * Jetpack related posts */ /** * The Gutenberg block */ .jp-related-posts-i2 { margin-top: 1.5rem; } .jp-related-posts-i2__list { --hgap: 1rem; display: flex; flex-wrap: wrap; column-gap: var(--hgap); row-gap: 2rem; margin: 0; padding: 0; list-style-type: none; } .jp-related-posts-i2__post { display: flex; flex-direction: column; /* Default: 2 items by row */ flex-basis: calc( ( 100% - var(--hgap) ) / 2 ); } /* Quantity qeuries: see https://alistapart.com/article/quantity-queries-for-css/ */ .jp-related-posts-i2__post:nth-last-child(n+3):first-child, .jp-related-posts-i2__post:nth-last-child(n+3):first-child ~ * { /* From 3 total items on, 3 items by row */ flex-basis: calc( ( 100% - var(--hgap) * 2 ) / 3 ); } .jp-related-posts-i2__post:nth-last-child(4):first-child, .jp-related-posts-i2__post:nth-last-child(4):first-child ~ * { /* Exception for 4 total items: 2 items by row */ flex-basis: calc( ( 100% - var(--hgap) ) / 2 ); } .jp-related-posts-i2__post-link { display: flex; flex-direction: column; row-gap: 0.5rem; width: 100%; margin-bottom: 1rem; line-height: 1.2; } .jp-related-posts-i2__post-link:focus-visible { outline-offset: 2px; } .jp-related-posts-i2__post-img { order: -1; max-width: 100%; } .jp-related-posts-i2__post-defs { margin: 0; list-style-type: unset; } /* Hide, except from screen readers */ .jp-related-posts-i2__post-defs dt { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(1px, 1px, 1px, 1px); white-space: nowrap; } .jp-related-posts-i2__post-defs dd { margin: 0; } /* List view */ .jp-relatedposts-i2[data-layout="list"] .jp-related-posts-i2__list { display: block; } .jp-relatedposts-i2[data-layout="list"] .jp-related-posts-i2__post { margin-bottom: 2rem; } /* Breakpoints */ @media only screen and (max-width: 640px) { .jp-related-posts-i2__list { display: block; } .jp-related-posts-i2__post { margin-bottom: 2rem; } } /* Container */ #jp-relatedposts { display: none; padding-top: 1em; margin: 1em 0; position: relative; clear: both; } .jp-relatedposts:after { content: ''; display: block; clear: both; } /* Headline above related posts section, labeled "Related" */ #jp-relatedposts h3.jp-relatedposts-headline { margin: 0 0 1em 0; display: inline-block; float: left; font-size: 9pt; font-weight: bold; font-family: inherit; } #jp-relatedposts h3.jp-relatedposts-headline em:before { content: ""; display: block; width: 100%; min-width: 30px; border-top: 1px solid #dcdcde; border-top: 1px solid rgba(0,0,0,.2); margin-bottom: 1em; } #jp-relatedposts h3.jp-relatedposts-headline em { font-style: normal; font-weight: bold; } /* Related posts items (wrapping items) */ #jp-relatedposts .jp-relatedposts-items { clear: left; } #jp-relatedposts .jp-relatedposts-items-visual { margin-right: -20px; } /* Related posts item */ #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post { float: left; width: 33%; margin: 0 0 1em; /* Needs to be same as the main outer wrapper for Related Posts */ box-sizing: border-box; -moz-box-sizing: border-box; -webkit-box-sizing: border-box; } #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post { padding-right: 20px; filter: alpha(opacity=80); -moz-opacity: .8; opacity: .8; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post:nth-child(3n+4), #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post:nth-child(3n+4) { clear: both; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post:hover .jp-relatedposts-post-title a { text-decoration: underline; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post:hover { filter: alpha(opacity=100); -moz-opacity: 1; opacity: 1; } /* Related posts item content */ #jp-relatedposts .jp-relatedposts-items-visual h4.jp-relatedposts-post-title, #jp-relatedposts .jp-relatedposts-items p, #jp-relatedposts .jp-relatedposts-items time { font-size: 14px; line-height: 20px; margin: 0; } #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post-nothumbs { position:relative; } #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post-nothumbs a.jp-relatedposts-post-aoverlay { position:absolute; top:0; bottom:0; left:0; right:0; display:block; border-bottom: 0; } #jp-relatedposts .jp-relatedposts-items p, #jp-relatedposts .jp-relatedposts-items time { margin-bottom: 0; } #jp-relatedposts .jp-relatedposts-items-visual h4.jp-relatedposts-post-title { text-transform: none; margin: 0; font-family: inherit; display: block; max-width: 100%; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post .jp-relatedposts-post-title a { font-size: inherit; font-weight: normal; text-decoration: none; filter: alpha(opacity=100); -moz-opacity: 1; opacity: 1; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post .jp-relatedposts-post-title a:hover { text-decoration: underline; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post img.jp-relatedposts-post-img, #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post span { display: block; max-width: 90%; overflow: hidden; text-overflow: ellipsis; } #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post img.jp-relatedposts-post-img, #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post span { height: auto; max-width: 100%; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post .jp-relatedposts-post-date, #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post .jp-relatedposts-post-context { opacity: .6; } /* Hide the date by default, but leave the element there if a theme wants to use css to make it visible. */ .jp-relatedposts-items .jp-relatedposts-post .jp-relatedposts-post-date { display: none; } /* Behavior when there are thumbnails in visual mode */ #jp-relatedposts .jp-relatedposts-items-visual div.jp-relatedposts-post-thumbs p.jp-relatedposts-post-excerpt { display: none; } /* Behavior when there are no thumbnails in visual mode */ #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post-nothumbs p.jp-relatedposts-post-excerpt { overflow: hidden; } #jp-relatedposts .jp-relatedposts-items-visual .jp-relatedposts-post-nothumbs span { margin-bottom: 1em; } /* List Layout */ #jp-relatedposts .jp-relatedposts-list .jp-relatedposts-post { clear: both; width: 100%; } #jp-relatedposts .jp-relatedposts-list .jp-relatedposts-post img.jp-relatedposts-post-img { float: left; overflow: hidden; max-width: 33%; margin-right: 3%; } #jp-relatedposts .jp-relatedposts-list h4.jp-relatedposts-post-title { display: inline-block; max-width: 63%; } /* * Responsive */ @media only screen and (max-width: 640px) { #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post { width: 50%; } #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post:nth-child(3n) { clear: left; } #jp-relatedposts .jp-relatedposts-items-visual { margin-right: 20px; } } @media only screen and (max-width: 320px) { #jp-relatedposts .jp-relatedposts-items .jp-relatedposts-post { width: 100%; clear: both; margin: 0 0 1em; } #jp-relatedposts .jp-relatedposts-list .jp-relatedposts-post img.jp-relatedposts-post-img, #jp-relatedposts .jp-relatedposts-list h4.jp-relatedposts-post-title { float: none; max-width: 100%; margin-right: 0; } } /* * Hide the related post section in the print view of a post */ @media print { .jp-relatedposts { display:none ; } } .amp-logo amp-img{width:371px} .amp-menu input{display:none;}.amp-menu li.menu-item-has-children ul{display:none;}.amp-menu li{position:relative;display:block;}.amp-menu > li a{display:block;} /* Inline styles */ div.acss138d7{clear:both;}div.acss0dcba{--relposth-columns:3;--relposth-columns_m:3;--relposth-columns_t:3;}div.acss7e51b{aspect-ratio:16/9;background:transparent url(https://i0.wp.com/jerz.setonhill.edu/wp-content/uploads/2025/03/Screenshot-2025-03-12-at-12.29.58%E2%80%AFPM.png?resize=150%2C150&ssl=1) no-repeat scroll 0% 0%;height:150px;max-width:150px;}div.acss020fa{color:#333333;font-family:Arial Narrow;font-size:11px;height:45px;}div.acssd8696{aspect-ratio:16/9;background:transparent url(https://i0.wp.com/jerz.setonhill.edu/wp-content/uploads/2025/03/Screenshot-2025-03-08-at-11.16.32%E2%80%AFPM.png?resize=150%2C150&ssl=1) no-repeat scroll 0% 0%;height:150px;max-width:150px;}div.acss79008{aspect-ratio:16/9;background:transparent url(https://i0.wp.com/jerz.setonhill.edu/wp-content/uploads/2022/04/sisko-facepalm.jpeg?resize=150%2C150&ssl=1) no-repeat scroll 0% 0%;height:150px;max-width:150px;}div.acss503b9{aspect-ratio:16/9;background:transparent url(https://i0.wp.com/jerz.setonhill.edu/wp-content/uploads/2025/02/TELEMMGLPICT000412909317_17399875139830_trans_NvBQzQNjv4BqqVzuuqpFlyLIwiB6NTmJwfSVWeZ_vEN7c6bHu2jJnT8.jpeg?resize=150%2C150&ssl=1) no-repeat scroll 0% 0%;height:150px;max-width:150px;}div.acss2a0fc{aspect-ratio:16/9;background:transparent url(https://i0.wp.com/jerz.setonhill.edu/wp-content/uploads/2025/02/Screenshot-2025-02-20-at-12.21.13%E2%80%AFPM.png?resize=150%2C150&ssl=1) no-repeat scroll 0% 0%;height:150px;max-width:150px;}div.acss12a58{aspect-ratio:16/9;background:transparent url(https://i0.wp.com/jerz.setonhill.edu/wp-content/uploads/2025/02/Screenshot-2025-02-16-at-11.51.31%E2%80%AFAM-600x537-1.png?resize=150%2C150&ssl=1) no-repeat scroll 0% 0%;height:150px;max-width:150px;} .icon-widgets:before {content: "\e1bd";}.icon-search:before {content: "\e8b6";}.icon-shopping-cart:after {content: "\e8cc";}

Two decades of Alzheimer’s research may be based on deliberate fraud that has cost millions of lives

Over the last two decades, Alzheimer’s drugs have been notable mostly for having a 99% failure rate in human trials. It’s not unusual for drugs that are effective in vitro and in animal models to turn out to be less than successful when used in humans, but Alzheimer’s has a record that makes the batting average in other areas look like Hall of Fame material.

And now we have a good idea of why. Because it looks like the original paper that established the amyloid plaque model as the foundation of Alzheimer’s research over the last 16 years might not just be wrong, but a deliberate fraud.

The suspicion that something was more than a little wrong with the model that is getting almost all Alzheimer’s research funding ($1.6 billion in the last year alone) began with a fight over the drug Simufilam. The drug was being pushed into trials by its manufacturer, Cassava Sciences, but a group of scientists who reviewed the drug maker’s claims about Simufilam believed that it was exaggerating the potential. So they did what any reasonable person would do: They purchased short sell positions in Cassava Sciences stock, filed a letter with the FDA calling for a review before allowing the drug to go to trial, and hired an investigator to provide some support for this position. —Daily Kos

Post was last modified on 23 Jul 2022 1:14 am

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Dennis G. Jerz

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